Many proteins are associated with telomerase RNA (TER, or hTR a for human telomerase RNA) depending on the stage of the cell cycle, but telomerase reverse transcriptase (TERT) provides the core enzymatic activity. 3, 4 Telomerase apparently also acts by capping telomeres, so that the terminal DNA will not be susceptible to DNA damage-response. Telomerase is a eukaryotic ribonucleoprotein that synthesizes telomeric DNA. 1 Work on both validation and development of therapeutics has recently been reviewed. For example, in prostate cancer, telomerase activity correlates with graded tumors, being maximal in high-grade prostate carcinoma. Indeed, approximately 90% of human tumors have been associated with up-regulation of telomerase. Among the viable targets is human telomerase, which maintains telomeres at the end of chromosomes, in large part by adding repeats of 5'-TTAGGG-3', thus foiling the process of normal cellular senescence and imparting a quality of immortalization to the cell. Several potential new therapies and targets have arisen from increasing knowledge of processes that govern carcinogenesis. For example, it is the second greatest cause of death in the U.S. While there have been many advances in the battle to control cancer, it remains a huge problem worldwide.
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